Thermo Fisher Scientific F12 Monoclonal Antibody (OTI1H5), TrueMAB
인간 F12 단백질을 인식하는 마우스 단클론 항체로, IHC(P)에서 1:150 희석 비율로 사용됩니다. 친화 크로마토그래피로 정제되었으며, PBS/BSA/글리세롤 완충액에 보관됩니다. 연구용으로 혈액 응고 및 섬유소용해 관련 연구에 적합합니다.
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Applications
Tested Application
- Immunohistochemistry (Paraffin) [IHC (P)]: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1H5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 73–372 of human F12 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This single-chain zymogen is converted to a two-chain serine protease with a heavy chain (alpha-factor XIIa) and a light chain.
The heavy chain contains two fibronectin-type domains, two EGF-like domains, a kringle domain, and a proline-rich domain, while the light chain contains only a catalytic domain.
Upon activation, further cleavage occurs in the heavy chain, producing beta-factor XIIa chains.
Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa.
Active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin.
It activates coagulation factors VII and XI.
Defects in this gene do not cause clinical symptoms; the only effect is prolonged whole-blood clotting time.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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