Thermo Fisher Scientific cGKI Polyclonal Antibody
Thermo Fisher Scientific의 cGKI Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하는 Rabbit IgG 항체입니다. Western blot, ELISA, IP 실험에 최적화되어 있으며, 고순도의 Affinity chromatography로 정제되었습니다. 연구용으로 혈관 평활근 이완 및 신경 기능 조절 관련 단백질 분석에 적합합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 609–659 on human protein kinase G alpha subunit |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
PRKG1 is a cGMP-dependent serine/threonine kinase involved in vascular smooth muscle relaxation and platelet aggregation inhibition. It plays a key role in cardiovascular and neuronal regulation, smooth muscle tone modulation, and cell growth.
This gene is highly expressed in smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala.
Isoforms Iα and Iβ share cGMP-binding and catalytic domains but differ in leucine/isoleucine zipper and autoinhibitory regions, resulting in distinct dimerization substrates and kinase activities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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