Thermo Fisher Scientific ASK1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  MSTEADEGIT FSVPPFAPSG FCTIPEGGIC RRGGAAAVGE GEEHQLPPPP PGSFWNVESA AAPGIGCPAA TSSSSATRGR GSSVGGGSRR TTVAYVINEA SQGQLVVAES EALQSLREAC ETVGATLETL HFGKLDFGET TVLDRFYNAD IAVVEMSDAF R
• Positive Samples: HeLa
• Cellular Location: Cytoplasm, Endoplasmic reticulum

Target Information

MAP3K5 (ASK1) is a serine/threonine kinase abundantly expressed in human heart and pancreas. It is activated in response to various extracellular stimuli such as cytokines, growth factors, and environmental stresses. ASK1 activates MKK4 and MKK6, which subsequently activate JNK and p38 MAP kinases. ASK1 is involved in TNFR and Fas signaling through TRAF family interactions and Daxx. Overexpression induces apoptosis, while inactive forms inhibit TNF-α–induced apoptosis. ASK1 is expressed in various human and mouse tissues.

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For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.