Thermo Fisher Scientific hnRNP L Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 282-589 of human HNRNPL (NP_0015242) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:hnRNP L,uniProtId:P14866-1,ncbiNodeId:9606,antigenRange:282-589,antigenLength:589,antigenImageFileName:PA5-88548_hnRNP_L_P14866-1_Rabbit.svg,antigenImageFileNamePDP:PA5-88548_hnRNP_L_P14866-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.05 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804991

Product Specific Information

Immunogen sequence: TWDYTNPNLS GQGDPGSNPN KRQRQPPLLG DHPAEYGGPH GGYHSHYHDE GYGPPPPHYE GRRMGPPVGG HRRGPSRYGP QYGHPPPPPP PPEYGPHADS PVLMVYGLDQ SKMNCDRVFN VFCLYGNVEK VKFMKSKPGA AMVEMADGYA VDRAITHLNN NFMFGQKLNV CVSKQPAIMP GQSYGLEDGS CSYKDFSESR NNRFSTPEQA AKNRIQHPSN VLHFFNAPLE VTEENFFEIC DELGVKRPSS VKVFSGKSER SSSGLLEWES KSDALETLGF LNHYQMKNPN GPYPYTLKLC FSTAQHAS; Positive Samples: U-87MG, HeLa, HepG2, A-549, HT-29, Mouse brain, Mouse ovary, Rat brain; Cellular Location: Cytoplasm, Nucleus, nucleoplasm

Target Information

Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.