Thermo Fisher Scientific AQP0 Polyclonal Antibody
Rabbit polyclonal antibody targeting human AQP0 for use in IHC, ICC/IF, and ELISA applications. Recognizes AQP0 involved in lens fiber cell structure and cataract development. Supplied as liquid, unconjugated form, 1 mg/mL concentration, stored at -20°C.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human AQP0, amino acids 21–120 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
AQP0 is the most abundant endogenous protein in the plasma membrane of lens fiber cells, functioning as both a water channel and adhesion molecule essential for lens fiber structure and organization. It features an additional pore constriction unique among aquaporins, potentially responsible for pore gating. The closed AQP0 pore holds three water molecules spaced too far apart for hydrogen bonding. The C-terminal domain undergoes extensive post-translational modifications, including truncations during lens aging, influenced by m-calpain and other proteases. These truncations may contribute to cataract formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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