Thermo Fisher Scientific SIX5 Polyclonal Antibody
SIX5 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 적합하며, Human 및 Mouse 시료 반응성. Antigen affinity chromatography로 정제, 고순도. 액상 형태로 -20°C에서 보관.
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Applications
- Western Blot (WB): Tested dilution 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from internal region of human SIX5 (UniProt ID: Q8N196-1, antigen range: 625–645, antigen length: 739) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635501 |
Product Specific Information
The antibody detects endogenous levels of total SIX5 protein.
Target Information
Six5 (homeobox protein SIX5), also known as SIX5, BOR2 or DMAHP (DM locus-associated homeodomain protein), is a transcription factor expressed in various structures of the adult eye.
Localized to the cytoplasm in early development and to the nucleus in later stages, Six5 regulates organogenesis and retinal formation.
It binds the 5'-TCA[AG][AG]TTNC-3' DNA sequence found in myogenin and IGFBP5 promoters, controlling transcription of associated mRNA.
Six5 interacts with DACH1 and is co-activated by EYA proteins.
Defects in the SIX5 gene cause branchio-oto-renal syndrome type 2 (BOR2), characterized by hearing loss, deep overbite, and myopia.
Two isoforms exist due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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