Thermo Fisher Scientific RNF216 Polyclonal Antibody
Rabbit 유래 다클론 항체로 Human RNF216 단백질(100–150 aa 영역)을 인식합니다. Western blot 및 Immunoprecipitation에 적합하며, 비결합형 액상 형태로 제공됩니다. 1 mg/mL 농도, 4°C 보관, 연구용 전용 제품입니다.
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- A304111Ax (2개 옵션)
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific RNF216 Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 100 to 150 of Human Ring Finger Protein 216 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Activation of NF-κB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by adapter molecules such as TRIF, TIRAP, and MyD88. Several regulatory mechanisms exist to control TLR signal transduction, including inhibition of TLR expression and signaling by molecules such as ST2 and SIGIRR. Another mechanism involves the ubiquitination of selected TLRs by TRIAD3A, an E3 ubiquitin-protein ligase. TRIAD3A binds to TLR4 and TLR9 (and to a lesser extent TLR3 and TLR5), catalyzing their ubiquitination. Overexpression of TRIAD3A promotes degradation of TLR4 and TLR9, reducing ligand-specific activation. Conversely, depletion of TRIAD3A enhances TLR activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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