Thermo Fisher Scientific NR4A2 Monoclonal Antibody (2C12)
NR4A2 단백질을 인식하는 Mouse monoclonal antibody로, Human 시료에 반응합니다. Western Blot 및 ELISA에 적합하며, Affinity chromatography로 정제된 액상 제품입니다. PBS(pH 7.4) 버퍼에 보존제 없이 제공되며, -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C12 |
| Immunogen | NR4A2 (NP_006177, 147 a.a. to approximately 250 a.a) partial recombinant protein with GST tag. MW of GST tag alone: 26 kDa |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GSLHNFHQNY VATTHMIEQR KTPVSRLSLF SFKQSPPGTP VSSCQMRFDG PLHVPMNPEP AGSHHVVDGQ TFAVPNPIRK PASMGFPGLQ IGHASQLLDT QVPS*
Target Information
The Nuclear receptor related 1 protein (Nurr1), also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2), is encoded by the NR4A2 gene in humans.
NURR1 is a member of the nuclear receptor family of intracellular transcription factors and plays a key role in maintaining the dopaminergic system of the brain.
Mutations in this gene are associated with disorders related to dopaminergic dysfunction, including Parkinson’s disease, schizophrenia, and manic depression.
Misregulation of this gene may also be associated with rheumatoid arthritis.
Four transcript variants encoding distinct isoforms have been identified, and additional splice variants may exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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