Thermo Fisher Scientific Sox17 Monoclonal Antibody (OTI3B10), TrueMAB
SOX17 단백질을 인식하는 Mouse monoclonal antibody로, Western blot, ICC/IF, Flow cytometry에 적합. 인체 유래 재조합 단백질(aa 177-414)로부터 제작. 고순도 Affinity chromatography 정제, PBS/BSA/glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:100 |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3B10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 177–414 of human SOX17 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
SOX17 (transcription factor SOX-17) belongs to the SRY-related HMB box family of transcription factors. It acts as a transcription regulator that binds target promoter DNA and bends the DNA. It binds to the sequences 5'-AACAAT-3' or 5'-AACAAAG-3'.
SOX17 modulates transcriptional regulation via WNT3A and inhibits Wnt signaling. It promotes degradation of activated CTNNB1.
SOX17 plays an essential role in the regulation of embryonic development and is required for normal looping of the embryonic heart tube and for normal development of the definitive gut endoderm.
Mutations in the gene can result in vesicoureteral reflux.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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