Thermo Fisher Scientific SURF1 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive control: Jurkat
• Predicted reactivity: Mouse (84%), Rat (82%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The SURF-1 protein plays a vital role in the assembly of complex IV (CIV or COX) of the mitochondrial respiratory chain. Expressed in the inner mitochondrial membrane, mutations of the SURF-1 gene generally cause cytochrome c oxidase complex IV deficiency. This deficiency leads to Leigh syndrome, a severe neurological disorder characterized by progressive encephalopathy and necrotic lesions in subcortical brain regions. SURF-1 mutations are associated with high embryonic lethality and early-onset mortality, as well as muscle weakness and motor performance deficits. Morphological abnormalities in heart, brain, and skeletal muscle are also common due to SURF-1 mutations.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.