Thermo Fisher Scientific RND3 Monoclonal Antibody (1D2)
RND3 단백질을 인식하는 Thermo Fisher Scientific의 마우스 단클론 항체. Western blot, IHC, ELISA에 적합하며 Human 시료 반응성. 액상형, 무보존제 PBS buffer, -20°C 보관. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3 µg/mL |
| ELISA | 0.3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1D2 |
| Immunogen | RND3 (AAH12513, 1 a.a. – approximately 244 a.a) full-length recombinant protein with GST tag (MW of GST tag alone: 26 KDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MKERRASQKL SSKSIMDPNQ NVKCKIVVVG DSQCGKTALL HVFAKDCFPE NYVPTVFENY TASFEIDTQR IELSLWDTSG SPYYDNVRPL SYPDSDAVLI CFDISRPETL DSVLKKWKGE IQEFCPNTKM LLVGCKSDLR TDVSTLVELS NHRQTPVSYD QGANMAKQIG AATYIECSAL QSENSVRDIF HVATLACVNK TNKNVKRNKS QRATKRISHM PSRPELSAVA TDLRKDKAKS CTVM
Target Information
Members of the Rho family of Ras-related GTPases, such as ARHE, regulate the organization of the actin cytoskeleton in response to extracellular growth factors.
Like Ras, Rho family members appear to cycle between an inactive GDP-bound form and an active GTP-bound form.
Three major regulators of Rho activity have been identified:
- RhoGDIs: interact with GDP-bound Rho proteins to maintain resting complex
- GEFs: promote GDP/GTP exchange leading to activation
- GAPs: stimulate GTP hydrolysis and return activated Rho protein to inactive form
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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