Thermo Fisher Scientific RHOA Monoclonal Antibody (1C10)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYVADIEVDG KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD LRNDEHTRRE LAKMKQEPVK PEEGRDMANR IGAFGYMECS AKTKDGVREV FEMATRAALQ ARRGKKKSGC LVL

Target Information

RhoA regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. It is involved in microtubule-dependent signaling required for myosin contractile ring formation during cytokinesis and plays an essential role in cleavage furrow formation.
RhoA is necessary for apical junction formation of keratinocyte cell-cell adhesion and serves as a target for Yersinia pestis and Yersinia pseudotuberculosis toxins.
It stimulates PKN2 kinase activity and may activate PLCE1. RhoA is activated by ARHGEF2, promoting GDP-GTP exchange, and is essential for SPATA13-mediated regulation of cell migration and adhesion dynamics.
The MEMO1-RHOA-DIAPH1 signaling pathway contributes to ERBB2-dependent microtubule stabilization at the cell cortex, controlling APC and CLASP2 localization via GSK3B regulation. Membrane-bound APC allows MACF1 localization for microtubule capture and stabilization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.