Thermo Fisher Scientific VDAC Polyclonal Antibody
Thermo Fisher Scientific의 VDAC Polyclonal Antibody는 인간, 마우스, 랫트 등 다양한 종에 반응하는 다클론 항체입니다. Western blot 및 IHC(P) 실험에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포 대사 및 아폽토시스 연구용으로 권장됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
- Publications: [References not provided]
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human VDAC1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.46 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2792547 |
Product Specific Information
- Keep as concentrated solution.
- Predicted Reactivity: Mouse (97%), Rat (97%), Xenopus laevis (85%), Pig (98%), Rabbit (99%), Chicken (93%), Sheep (99%), Rhesus Monkey (98%), Bovine (99%)
- Positive Control: A431, H1299, HeLa, HepG2, F05, F32, F39, F90
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Voltage-dependent anion channel (VDAC) proteins are abundant, pore-forming proteins belonging to the eukaryotic mitochondrial porins. They are located in the mitochondrial outer membrane and also expressed in the plasma membrane.
At least three different VDAC genes have been identified in vertebrates. VDAC proteins play an essential role in cellular metabolism and in the early stages of apoptosis.
VDAC constitutes a major pathway for metabolite exchange (ADP/ATP, succinate, citrate) between cytosol and mitochondria. VDAC1 in the plasma membrane may regulate apoptosis via its redox activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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