Thermo Fisher Scientific AIRE Polyclonal Antibody
AIRE 단백질을 인식하는 염소 폴리클로날 항체로, Western blot 및 IHC(P)에서 검증됨. 인간 및 돼지 반응성. 합성 펩타이드 면역원 기반, 비결합형 액상 형태. TBS(pH 7.3) 버퍼, -20°C 보관.
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1.0 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Pig |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (KDVDLSQPRKGRKP) corresponding to internal amino acids of AIRE (aa 102–115) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10987323 |
Product Specific Information
- Predicted to react with bovine, canine, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
AIRE is a transcriptional regulator protein that binds DNA as a dimer and tetramer, but not as a monomer. It is involved in gene expression regulation and immune tolerance.
AIRE is a 545 amino acid nuclear protein containing an HSR domain, two PHD-type zinc fingers, and a SAND domain. It can form homodimers, homotetramers, and nuclear bodies, and interacts with transcriptional coactivators CBP and CREBBP.
Three isoforms of AIRE are reported, one predicted to be a candidate for nuclear-mediated decay (NMD).
Defects in AIRE cause autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), a rare autosomal-recessive autoimmune disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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