Thermo Fisher Scientific Thioredoxin 1 Polyclonal Antibody
Human Thioredoxin 1을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF 등 다양한 응용에 적합함. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보존. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TXN. Recombinant protein control fragment (Product #RP-103792). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2791020 |
Product Specific Information
Immunogen sequence:
SLSEKYSNVI FLEVDVDDCQ DVASECEVKC MPTFQFFKKG QKVGEFSGA
Target Information
Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx acts as a hydrogen donor for ribonucleotide reductase, an essential enzyme for DNA synthesis, and functions as a general protein disulfide reductase involved in growth and redox regulation. Specific targets for Trx-mediated reduction include protein disulfide-isomerase (PDI) and transcription factors such as p53, NF-κB, and AP-1. Trx also helps remove H₂O₂, particularly when coupled with methionine sulfoxide reductase or peroxiredoxin isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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