Thermo Fisher Scientific ADAM10 Recombinant Mouse Monoclonal Antibody (6A8)

Applications

Flow Cytometry (Flow)

• Tested Dilution: 1:20–1:500

ELISA

• Tested Dilution: Assay-dependent

Product Specifications

Target Information

Proinflammatory cytokine tumor necrosis factor-a (TNF-a) contributes to various inflammatory responses and programmed cell death.
Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including T-cell lymphoma.
TNF-a, Notch, and its ligand Delta are membrane-bound molecules cleaved by proteases to release mature proteins or functional receptors.
ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (a disintegrin and metalloprotease), was identified to cleave TNF-a, Notch, and Delta.
Human, mouse, and bovine ADAM10 genes were cloned and designated ADAM10, Kuzbanian (KUZ), and MADM, respectively.
ADAM10 mRNA is expressed in various human and bovine tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.