Thermo Fisher Scientific PSMC2 Monoclonal Antibody (1851CT193.4.40)

Applications

• Western Blot (WB)
  Tested Dilution: 1:2,000

Product Specifications

Target Information

Proteolytic degradation is critical for maintaining appropriate levels of short-lived and regulatory proteins involved in metabolism, stress response, antigen presentation, receptor modulation, ion channels, cell cycle regulation, transcription, and signaling.
The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cytosol and nucleus, while others are degraded through the vacuolar pathway involving endosomes, lysosomes, and the endoplasmic reticulum.

The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine (~2.5 MDa) composed of a 20S proteolytic core and one or two 19S regulatory subunits. The 19S subunits recognize ubiquitinated proteins and facilitate their unfolding and translocation into the 20S core.
An enzymatic cascade attaches multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Defects in this pathway are linked to genetic diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.