Thermo Fisher Scientific Contactin 2 Monoclonal Antibody (8B9F4G1)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:1,000–1:2,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human CNTN2/TAG-1.

Target Information

Contactin 2 (CNTN2, also known as transiently-expressed axonal glycoprotein, AXT, TAX, TAX1, TAG-1, axonin 1) is a neuronal cell adhesion molecule (CAM) that influences the formation of axon connections in the developing nervous system.
Contactin 2 is a member of the immunoglobulin superfamily (IgSF) and contains a glycosylphosphatidylinositol-anchor, six immunoglobulin (Ig)-like and four Fibronectin type III (FNIII)-like domains.
It is expressed predominantly during neural development on the cell membrane of axons in nerve fiber tracts to guide commissural axons without promoting their growth.
Contactin 2 binds with NgCAM in the plane of the same membrane (cis-binding).
The heterophilic (Contactin 2/NgCAM and Contactin 2/NrCAM) binding sites are localized to the first four Ig domains, whereas the homophilic (Contactin 2/Contactin 2) binding site is localized to the FNIII domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.