Thermo Fisher Scientific Par4 Polyclonal Antibody
Rabbit polyclonal antibody targeting human PAR4 protein for WB and IP applications. Recognizes region 225–275 of PAR4 involved in apoptosis regulation. Supplied as liquid, unconjugated form at 0.2 mg/mL. Stored at 4°C, shipped on wet ice.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 225 and 275 of human prostate apoptosis response protein 4 (PRKC, apoptosis, WT1, regulator) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms.
- Intracellular mechanism: Inhibition of pro-survival pathways and activation of Fas-mediated apoptosis.
- Extracellular mechanism: Binding of secreted form to GRP78 on the cell surface, activating the extrinsic apoptotic pathway.
This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated in different tumors.
The encoded protein also plays an important role in the progression of age-related diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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