Thermo Fisher Scientific MIP-3 beta Monoclonal Antibody (87102)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute at 0.5 mg/mL in sterile PBS.
• Endotoxin level: <0.10 EU per 1 µg of antibody (LAL method).

Target Information

CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC subfamily of chemokines. It is closely related to CCL21, sharing approximately 32% amino acid sequence homology.
CCL19 and CCL21 are primarily expressed by stromal cells in the T cell-rich zones of lymph nodes. They play key roles in the homeostatic trafficking of naive T cells and activated dendritic cells into secondary lymphoid organs, as well as in T cell priming, activation, and lymphocyte recruitment to inflamed tissues.
Both signal via the G protein-coupled receptor CCR7, which is expressed on T cells and mature dendritic cells. While both ligands bind CCR7 with similar affinity, only CCL19 binding induces receptor desensitization and internalization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.