Thermo Fisher Scientific MIP-3 beta Monoclonal Antibody (87102)
Thermo Fisher Scientific의 MIP-3 beta 단클론 항체(87102)는 Mouse 시료에 반응하며 Western blot, ELISA, Neutralization에 적합합니다. Rat IgG2a 형식의 비결합 항체로, Protein A/G로 정제되었으며 동결건조 형태로 제공됩니다. 연구용 전용 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| ELISA (Detection) | 0.1–0.4 µg/mL |
| ELISA (Capture) | 2–8 µg/mL |
| Neutralization (Neu) | 3–15 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 87102 |
| Immunogen | E. coli-derived recombinant mouse CCL19/MIP-3 beta (Gly26–Val107–Leu-Glu, Ser108LeuGlu) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2610117 |
Product Specific Information
- Reconstitute at 0.5 mg/mL in sterile PBS.
- Endotoxin level: <0.10 EU per 1 µg of antibody (LAL method).
Target Information
CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC subfamily of chemokines. It is closely related to CCL21, sharing approximately 32% amino acid sequence homology.
CCL19 and CCL21 are primarily expressed by stromal cells in the T cell-rich zones of lymph nodes. They play key roles in the homeostatic trafficking of naive T cells and activated dendritic cells into secondary lymphoid organs, as well as in T cell priming, activation, and lymphocyte recruitment to inflamed tissues.
Both signal via the G protein-coupled receptor CCR7, which is expressed on T cells and mature dendritic cells. While both ligands bind CCR7 with similar affinity, only CCL19 binding induces receptor desensitization and internalization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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