Thermo Fisher Scientific CLCN1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CLCN1, validated for WB and IHC applications. High purity (>95%) via antigen affinity chromatography. Supplied as liquid form at 1 mg/mL in PBS with glycerol and sodium azide. Suitable for research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length Human CLCN1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720538 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% as determined by SDS-PAGE.
Target Information
The family of voltage-dependent chloride channels (CLCs) regulates cellular trafficking of chloride ions, essential for cellular excitability and volume maintenance.
- CLCN1: Highly expressed in skeletal muscle; mutations cause myotonia, characterized by muscle stiffness and renal salt wasting.
- CLCN2: Expressed in lung epithelia; potential therapeutic target for cystic fibrosis.
- CLCN3: Abundant in neuronal tissue.
- CLCN4: Found in skeletal, cardiac muscle, and brain.
- CLCN5: Mutations lead to Dent’s disease (proteinuria, hypercalciuria).
- CLCN6/7: Broadly expressed in testis, kidney, brain, and muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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