Thermo Fisher Scientific Aggrecan Polyclonal Antibody
Thermo Fisher Scientific의 Aggrecan Polyclonal Antibody는 인간, 마우스, 랫트에 반응하며 WB, IHC, ICC, ELISA 등에 사용 가능합니다. KLH 결합 합성 펩타이드(aa 601–700)를 면역원으로 한 Rabbit IgG 항체로, 단백질 A로 정제되어 1 mg/mL 농도로 제공됩니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from Human Aggrecan, amino acids 601–700 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Aggrecan, also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is encoded by the ACAN gene. It is a key extracellular matrix component in cartilaginous tissue, providing resistance to compression.
The human aggrecan protein (~250 kDa, 2316 amino acids) can be expressed in multiple isoforms due to alternative splicing. It has a bottlebrush structure with chondroitin sulfate and keratan sulfate chains attached to a protein core.
Aggrecan synthesis and degradation are crucial in cartilage deterioration during joint injury, disease, and aging. It contains three interglobular domains (G1, G2, G3) involved in aggregation, hyaluronan binding, cell adhesion, and chondrocyte apoptosis.
Aggrecan fragments are released into synovial fluid during osteoarthritis progression due to cleavage by aggrecanase and MMP activity. Antibodies BC-3 and BC-4 detect neo-epitopes of Aggrecanase (ARGSVXXX) and MMP (XXXVDIPEN), respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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