Thermo Fisher Scientific APOBEC3G Polyclonal Antibody
APOBEC3G 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot 및 IHC(P)에서 검증됨. 고순도 액상 형태로 제공되며, 인간 단백질에 반응. 연구용으로 HIV-1 관련 기전 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 118–148 from the central region of human APOBEC3G (CEM15) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.8 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2057410 |
Target Information
The Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) 3 family belongs to the cytidine deaminase enzyme group that acts on monomeric nucleosides and nucleotides. APOBEC3 proteins play a key role in cellular defense against retroviral infection. Specifically, APOBEC3G and, to a lesser extent, APOBEC3F can be incorporated into HIV-1 virions and induce hypermutation in newly synthesized viral DNA, destabilizing the viral genome. This antiviral activity is counteracted by the HIV-1 Vif protein, which promotes APOBEC3G degradation. A single amino acid substitution (D128K) can prevent APOBEC3G depletion without impairing its inhibitory function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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