Thermo Fisher Scientific MAP3K7 Monoclonal Antibody (OTI9D2), TrueMAB
Human MAP3K7 단백질(254-367 aa)에 특이적인 Mouse monoclonal antibody(OTI9D2). Western blot에 적합하며, TAK1 신호전달 연구에 활용 가능. Affinity chromatography로 정제된 1 mg/mL 액상 항체로, PBS/BSA/glycerol buffer에 보존. 연구용 전용 시약.
- 카탈로그번호
- TA809633
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9D2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 254–367 of human MAP3K7 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TAK1 (also known as MAP3K7) is a serine/threonine kinase with multiple signaling functions. Initially identified as a TGF-β-activated kinase, it interacts with TGF-β receptor and TRAF6 to regulate activation of JNK and p38 pathways. TAK1 also participates in Wnt, BMP, and activin signaling, and responds to thyroid hormone, osmotic stress, endothelin, and ephrine.
It promotes proper wound healing by repressing PDGF-B, integrin β1, and integrin β5 through activation of the von Hippel-Lindau tumor suppressor. TAK1 plays a central role in IKK activation in IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I pathways. This activation involves TAB2/3-mediated ubiquitination and TAK1 autophosphorylation at Thr178, Thr184, Thr187, and Ser192, leading to phosphorylation of IKK-β. Additionally, TAK1 represses human telomerase reverse transcriptase, suggesting a role in cell lifespan regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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