ELK Biotechnology ARC rabbit pAb

제품명

ARC rabbit pAb

적용 분야

• Western Blot (WB)
• ELISA

권장 희석 배수

• WB: 1:500–1:2000
• ELISA: 1:5000–1:20000

면역원

• 인간 ARC 단백질 유래 합성 펩타이드 (AA range: 70–150)

저장 조건

• 종: Rabbit
• 온도: -20°C
• 보관 기간: 1년

항체 특성

세포 내 위치

Extracellular vesicle membrane; Lipid-anchor.
Cell junction, synapse, postsynaptic cell membrane; Lipid-anchor.
Cell junction, synapse; postsynaptic density; Early endosome membrane; Cell projection, dendrite; Cytoplasm, cytoskeleton; Cytoplasm, cell cortex; Cell projection, dendritic spine; Cytoplasmic vesicle, secretory vesicle, acrosome.
Forms virion-like extracellular vesicles released from neurons. Enriched in postsynaptic density of dendritic spines. Targeted to inactive synapses following interaction with CAMK2B in inactive kinase state. Accumulation at weaker synapses may prevent undesired enhancement. Associated with neuronal soma and dendritic cortex. Also associated with sperm tail.

배경 정보

Required for consolidation of synaptic plasticity and formation of long-term memory.
Regulates endocytosis of AMPA receptors in response to synaptic activity.
Essential for homeostatic synaptic scaling of AMPA receptors.
Belongs to ARC/ARG3.1 family.
Associated with neuronal soma and dendritic cortex, enriched in postsynaptic density of dendritic spines, and found in sperm tail.
Interacts with SH3GL1 (endophilin-2), SH3GL3 (endophilin-3), and DNM2 (DYN2).