ELK Biotechnology LECT1 rabbit pAb
LECT1 단백질을 인식하는 토끼 다클론 항체로, WB 및 ELISA에 사용 가능. 인간, 랫드, 마우스 시료에 반응하며, 세포외 기질 단백질 연구에 적합. 1 mg/ml 농도, -20°C에서 1년 보관 가능.
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ELK Biotechnology LECT1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | LECT1 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB: 1:500–2000, ELISA: 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 150–230) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 36 kD |
| Gene ID (Human) | 11061 |
| Human Swiss-Prot No. | O75829 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | [Chondromodulin-1]: Secreted, extracellular space, extracellular matrix. Accumulated in the inter-territorial matrix of cartilage. [Chondrosurfactant protein]: Endomembrane system; Single-pass membrane protein. |
Background
This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein.
The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein, although no biological activity has yet been defined for it.
The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1.
The mature protein promotes chondrocyte growth and inhibits angiogenesis.
This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion.
The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone.
It may also be involved in the broad control of tissue vascularization.
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