ELK Biotechnology PHB2 rabbit pAb

제품명

PHB2 rabbit pAb

제품 개요

PHB2 단백질에 특이적인 rabbit polyclonal antibody로, Western Blot(WB) 및 ELISA 실험에 적합합니다. 인간, 생쥐, 랫트 시료에서 반응하며, 세포 내 다양한 부위에서 발현되는 PHB2 단백질의 검출에 유용합니다.

제품 정보

Background

• Developmental stage: Expression in fibroblasts decreases heterogeneously during cellular aging.
• Function: Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.
• Induction: Expression increases approximately 3-fold upon entry into G1 phase compared to other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol.
• Similarity: Belongs to the prohibitin family.
• Subcellular location: Also cytoplasmic and nuclear.
• Subunit: Interacts with PHB, ESR1, HDAC1, and HDAC5.