ELK Biotechnology MYH11 rabbit pAb
MYH11 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 사용 가능. 인간, 랫트, 마우스에 반응하며, 1 mg/ml 농도의 IgG 형태로 제공. -20°C에서 1년 보관 가능. 평활근 미오신 연구 및 암 관련 단백질 분석에 적합.
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ELK Biotechnology MYH11 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | MYH11 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 216 kD |
| Gene ID (Human) | 4629 |
| Human Swiss-Prot No. | P35749 |
| Cellular Localization | Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils. |
| Species Reactivity | Human; Rat; Mouse |
Background
The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP.
The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3′ end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype.
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