ELK Biotechnology KPCI rabbit pAb
KPCI rabbit polyclonal antibody로 WB 및 ELISA에 사용 가능. 인간 단백질 유래 합성 펩타이드로 면역화됨. 세포질, 막, 핵 등 다양한 세포 위치에서 발현. -20°C에서 1년 보관 가능. Human, Mouse, Rat 반응성.
- 카탈로그번호
- ES10824-xxxxx (2개 옵션)
- 판매단위
- pk
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ELK Biotechnology KPCI rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | KPCI rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–1:2000, ELISA 1:5000–1:20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 65 kD |
| GeneID (Human) | 5584 |
| Human Swiss-Prot No | P41743 |
| Cellular Localization | Cytoplasm, Membrane, Endosome, Nucleus. Transported into the endosome through interaction with SQSTM1/p62. After phosphorylation by SRC, transported into the nucleus through interaction with KPNB1. Colocalizes with CDK7 in the cytoplasm and nucleus. Transported to vesicular tubular clusters (VTCs) through interaction with RAB2A. |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbol esters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where it phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. It is necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]
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