Thermo Fisher Scientific CD8A Monoclonal Antibody (OTI7C10), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family involved in signal transduction and T cell activation.
CD8 is mainly expressed on T cells as a disulfide-linked heterodimer (CD8α/CD8β) and functions as a co-receptor with the T cell receptor (TCR) for MHC class I molecules.
It is also found on NK cells, monocytes, and dendritic cells as CD8α homodimers.
Upon MHC-I/peptide complex binding, CD8 recruits Lck kinase, leading to cytokine production, motility, and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs are essential for eliminating pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.