Thermo Fisher Scientific MLH3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

10 µg/mL

-

Flow Cytometry (Flow)

10 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide with sequence RQSLQQSMPPCEPP. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MLH3,uniProtId:Q9UHC1-1,ncbiNodeId:9606,antigenRange:1440-1453,antigenLength:1453,antigenImageFileName:PA5-142010_MLH3_Q9UHC1-1_Goat.svg,antigenImageFileNamePDP:PA5-142010_MLH3_Q9UHC1-1_Goat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2932673

Product Specific Information

Additional Information: This antibody is expected to recognize isoform 1 (NP_001035197.1) and isoform 2 (NP_055196.2).

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:2,000.

Target Information

This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.