Thermo Fisher Scientific MLH3 Polyclonal Antibody
MLH3 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. ICC/IF 및 유세포분석에 사용 가능하며 인간 시료에 반응. 0.5 mg/mL 농도의 액상 형태로 제공되며 -20°C에서 보관. 유전자 불일치 복구 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence RQSLQQSMPPCEPP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2932673 |
Product Specific Information
- This antibody is expected to recognize isoform 1 (NP_001035197.1) and isoform 2 (NP_055196.2).
- Tested in Peptide ELISA: antibody detection limit dilution 1:2,000.
Target Information
This gene belongs to the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are essential for maintaining genomic integrity during DNA replication and meiotic recombination. The MLH3 protein forms a heterodimer with other family members. Somatic mutations in this gene are frequently found in tumors exhibiting microsatellite instability, and germline mutations are associated with hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants exist, with two full-length variants identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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