Thermo Fisher Scientific CLAC-P Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total Collagen XXV alpha 1.

Target Information

Alzheimer’s disease (AD) is characterized by deposition of beta-amyloid as senile plaques and cerebral amyloid angiopathy. The principal component of AD amyloid is the amyloid beta peptide (Aβ). Although production and deposition of Aβ appear closely related to the pathogenesis of AD, evidence suggests that Aβ alone is not sufficient to cause neuronal death and dementia symptoms.
A component of senile plaque (SP), CLAC (collagen-like Alzheimer amyloid plaque component) and its precursor CLAC-P, are deposited with extracellular beta-amyloid and have been implicated in beta-amyloid–induced cell toxicity in AD brains. CLAC-P is a unique, membrane-bound collagen-like structure containing three Gly-X-Y repeat motifs and may represent a novel class of neuronal collagens.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.