Thermo Fisher Scientific FceR1 alpha Monoclonal Antibody (CRA2 (AER24)), Biotin

Thermo Fisher Scientific FceR1 alpha Monoclonal Antibody (CRA2 (AER24)), Biotin

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA1-4999 detects Fc epsilonR1 alpha (Biotin) from human samples.
The CRA2 (AER24) monoclonal antibody reacts with the Fc epsilonR1 alpha subunit on a region overlapping the IgE binding site, thus it competes with IgE for receptor binding.
MA1-4999 has been successfully used in Western blot, flow cytometry, and immunohistochemistry applications.
The immunogen corresponds to the region of Fc epsilonR1 alpha overlapping the IgE binding site (Swiss protein P12319).
Epitope mapped to amino acids 110–197.

Target Information

FceR1 (Fc epsilonR1 alpha) is a subunit of the high-affinity receptor for IgE. It forms a tetrameric complex consisting of one alpha, one beta, and two additional subunits responsible for signal transduction.
This receptor plays a key role in triggering allergic responses. When allergen-bound IgE molecules crosslink two or more high-affinity IgE receptors, mediators such as histamine are released, leading to allergy symptoms.
The IgE receptor couples allergen and mast cells to initiate inflammatory responses characteristic of disorders such as hay fever and asthma.
The release of histamine and proteases induces synthesis of prostaglandins and leukotrienes, potent effectors of hypersensitivity responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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