Thermo Fisher Scientific FceR1 alpha Monoclonal Antibody (CRA2 (AER24)), Biotin

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent

-

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent

-

Flow Cytometry (Flow)

Assay-dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

CRA2 (AER24)

Immunogen

Region of FceR1 alpha (aa 26-197). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:FceR1 alpha,uniProtId:P12319-1,ncbiNodeId:9606,antigenRange:26-197,antigenLength:257,antigenImageFileName:MA1-4999_FceR1_alpha_P12319-1_House_mouse.svg,antigenImageFileNamePDP:MA1-4999_FceR1_alpha_P12319-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Biotin Biotin Biotin

View additional formats

• Unconjugated
• Request custom conjugation

Form

Liquid

Concentration

1 mg/mL

Purification

purified

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1956170

Product Specific Information

MA1-4999 detects Fc epsilonR1 alpha (Biotin) from human samples. The CRA2 (AER24) monoclonal antibody reacts with the Fc epsilonR1 alpha subunit on a region that overlaps the region of the IgE binding site, thus it competes with IgE for the receptor bindi

MA1-4999 has been successfully used in Western blot, flow cytometry, and immunohistochemistry applications.

The MA1-4999 immunogen is region of Fc epsilonR1 alpha which overlaps with the IgE binding site; Swiss protein P12319.

The epitope has been mapped to amino acids 110-197.

Target Information

FceR1 (Fc epsilonR1 alpha) is a subunit of the high affinity receptor of IgE. Fc epsilonR1 alpha is a tetrameric complex consisting of one alpha, one ß and two additional subunits. The latter two are required for signal transduction activity. The Fc epsilonR1 complex plays an important role in triggering allergic responses, and the immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine, which are responsible for allergy symptoms, are released. The IgE receptor couples allergen and mast cells to initiate the inflammatory responses that are characteristic of disorders such as hay fever and asthma. The release of histamine and proteases leads to the synthesis of prostaglandins and leukotrienes-potent effectors of the hypersensitivity response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.