Thermo Fisher Scientific ALKBH4 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ALKBH4. Recombinant protein control fragment (Product #RP-98508). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ALKBH4,uniProtId:Q9NXW9-1,ncbiNodeId:9606,antigenRange:43-114,antigenLength:302,antigenImageFileName:PA5-62407_ALKBH4_Q9NXW9-1_Rabbit.svg,antigenImageFileNamePDP:PA5-62407_ALKBH4_Q9NXW9-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2637867

Product Specific Information

Immunogen sequence: TYRFIYCSDT GWAVGTEESD FEGWAFPFPG VMLIEDFVTR EEEAELVRLM DRDPWKLSQS GRRKQDYGPK VN

Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 79%.

Target Information

Dioxygenase that mediates demethylation of actin monomethylated at Lys-84 (K84me1), thereby acting as a regulator of actomyosin-processes (PubMed:23673617). Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (PubMed:23673617). In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.