Thermo Fisher Scientific Phospho-LGR5 (Thr842) Polyclonal Antibody
LGR5 단백질의 Thr842 인산화 형태를 특이적으로 검출하는 폴리클로날 항체로, Western blot에 적합합니다. 인간, 생쥐, 랫트 시료에 반응하며, 고순도 정제 및 PBS/glycerol 용액 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA5105744
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- pk
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Thermo Fisher Scientific Phospho-LGR5 (Thr842) Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LGR5 (Accession O75473), corresponding to amino acid residues around phosphorylated Thr842 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817143 |
Product Specific Information
This antibody detects endogenous levels of LGR5 only when phosphorylated at Thr842.
Target Information
G protein-coupled receptor GPR49 (LGR5) is expressed in brain, skeletal muscle, placenta, and spinal cord. ESTs have been isolated from normal human brain (amygdala), embryo, and placenta libraries, as well as from germ cell, uterus, and brain libraries.
GPCRs represent one of the largest families of signaling molecules, sharing a structural motif of seven transmembrane helices and existing in active/inactive forms. Activation leads to G-protein signaling and downstream effects, while negative regulation mechanisms modulate cellular responses.
GPCR-targeted drugs such as Zyprexa (Eli Lilly) and Claritin (Schering-Plough) exemplify the pharmacological significance of this receptor family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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