Thermo Fisher Scientific ATM Monoclonal Antibody (5C2)
ATM 단백질을 인식하는 5C2 클론의 Mouse monoclonal antibody. Western blot, IHC, ICC/IF, IP 등 다양한 응용에 사용 가능. Human, Mouse, Rat, Non-human primate 반응성. Protein G 정제, PBS 용액, 1 mg/mL 농도. DNA 손상 복구 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5C2 |
| Immunogen | Recombinant protein corresponding to amino acids 980–1512 of ATM (UniProt ID: Q13315-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1185574 |
Product Specific Information
- Recommended positive controls: Raji, HeLa nuclear extract.
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family.
Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.
The ATM gene encodes a protein kinase that phosphorylates key regulators of the cell cycle including p53, Mdm2, BRCA1, and SMC1.
ATM plays a critical role in repairing double-stranded DNA breaks caused by ionizing radiation and other mutagens. The C-terminal region of ATM shares homology with catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases).
Upon exposure to ionizing radiation, ATM becomes autophosphorylated and activates downstream signaling pathways regulating cell cycle, apoptosis, and DNA damage repair.
ATM, along with Nbs1 and Chk2, is involved in the E2F1-mediated apoptosis pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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