Thermo Fisher Scientific PTGER3 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–3 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey, Panda, Bat (100%); Mouse (94%); Xenopus (88%); Bovine, Pig, Opossum (82%).

Target Information

CD172a, also known as signal-regulatory protein alpha, is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells, and hematopoietic stem cells.
CD172a acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src, and insulin receptor, and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways.

Ligand binding of CD172a to integrin-associated protein CD47 results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of CD172a, mediating the recruitment and activation of tyrosine phosphatases SHP-1 and SHP-2.
These phosphatases regulate cellular function through dephosphorylation of specific substrates.

Ligation of CD172a with CD47 has been demonstrated in several regulatory processes, including inhibition of host cell phagocytosis by macrophages and bi-directional activation of T cells and dendritic cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.