Thermo Fisher Scientific RYBP Polyclonal Antibody
RYBP 단백질 검출용 Thermo Fisher Scientific의 rabbit polyclonal antibody. Western blot, IHC, ICC/IF 등 다양한 응용 가능. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태로 4°C 보관.
- 카탈로그번호
- PA519943
- 판매단위
- pk
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Thermo Fisher Scientific RYBP Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | DEDAF antibody was raised against a 14 amino acid peptide near the carboxy terminus of human DEDAF. The immunogen is located within the last 50 amino acids of DEDAF. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153692 |
Product Specific Information
- In Western blot applications, this antibody detects a band at approximately 32 kDa.
- Suggested positive control: A549 cell lysate.
- PA5-19943 can be used with blocking peptide PEP-0068.
Target Information
RYBP is a component of a Polycomb group (PcG) multiprotein PRC1-like complex, which maintains transcriptional repression of genes such as Hox throughout development.
This complex acts via chromatin remodeling and histone modification, mediating monoubiquitination of histone H2A (Lys-119), leading to heritable changes in gene expression.
RYBP is required for normal silencing of one X chromosome in XX females and may recruit the complex to target sites to stimulate ubiquitination of H2A.
It inhibits ubiquitination and degradation of TP53, regulating transcription of TP53 target genes, and may influence proteasomal degradation of other proteins like FANK1 to regulate apoptosis.
RYBP may act as a transcriptional repressor and DNA-binding protein, potentially involved in tumor suppression in breast cancer through down-regulation of SRRM3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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