Thermo Fisher Scientific NFIX Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Recommended positive controls: 293T
• Predicted reactivity: Mouse (99%), Xenopus laevis (85%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

NF-1, also designated CTF, consists of a family of CCAAT box binding proteins that stimulate DNA replication and activate transcription.
Analysis of human NF-1 messenger RNA has revealed two forms of the NF-1 protein arising from an alternate splicing of a single NF-1 gene.
NF-1 binds its consensus DNA element as a homodimer via an amino-terminal DNA binding domain and activates transcription through a proline-rich, carboxy terminal transactivation domain.
The NF-1 protein recognizes and binds the adenovirus type 2 promoter and activates transcription of herpes simplex virus thymidine kinase genes.
The NF-1 consensus element has been found in the upstream promoter region of numerous eukaryotic genes, including Ha-Ras, alpha-globin, HSP70, GRP78, Histone H1, myelin basic protein, and the Xenopus laevis vitellogenin gene promoter.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.