Thermo Fisher Scientific CRHBP Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In direct ELISAs, approximately 30% cross-reactivity with recombinant mouse CRHBP is observed.
• Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

Response to stress in mammals requires an intact hypothalamic-pituitary-adrenal axis. The proximal part of the response is mediated by secretion of corticotropin-releasing hormone (CRH) by the paraventricular nucleus of the hypothalamus. CRH is a 41 amino acid peptide derived by enzymatic cleavage from a 191 amino acid preprohormone. CRH is produced not only in the hypothalamus but also in peripheral tissues, such as T lymphocytes, and is highly expressed in human placenta. Glucocorticoids stimulate placental CRH synthesis and secretion in primary cultures of human placenta, contrasting with glucocorticoid suppression of CRH expression in the hypothalamus. The gene encoding CRH maps to human chromosome 8q13. Human plasma contains a CRH-binding protein (CRH-BP, also known as CRF-BP) that inactivates CRH and may prevent inappropriate pituitary-adrenal stimulation during pregnancy. The gene encoding CRF-BP maps to human chromosome 5q11.2–q13.3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.