Thermo Fisher Scientific SATB1 Monoclonal Antibody (OTI3E12), TrueMAB
인간 SATB1 단백질을 인식하는 Mouse IgG1 단클론 항체로, WB(1:2,000) 및 IHC-P(1:50)에 적합합니다. 액상 형태이며 PBS/BSA/glycerol 버퍼에 보관됩니다. Affinity chromatography로 정제되어 고순도이며 연구용으로만 사용됩니다.
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Thermo Fisher Scientific SATB1 Monoclonal Antibody (OTI3E12), TrueMAB
Applications and Tested Dilution
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC-P): 1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3E12 |
| Immunogen | Full length human recombinant protein of human SATB1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.93 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
SATB1 (DNA-binding protein SATB1) is a crucial silencing factor involved in X inactivation mediated by Xist RNA during embryogenesis and in lymphoma.
It binds to AT-rich sequences and nuclear matrix-associated regions, recognizing the sugar-phosphate structure of double-stranded DNA.
SATB1 functions as a transcriptional repressor regulating nuclear and viral gene expression in a phosphorylation- and acetylation-dependent manner.
It modulates genes essential for the maturation of immune T-cell CD8SP from thymocytes.
SATB1-binding sites are preferentially targeted by HIV-1 integration machinery, and HIV-1 Tat may overcome SATB1-mediated repression in T-cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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