Thermo Fisher Scientific CRYAB Monoclonal Antibody (OTI3C2), TrueMAB
CRYAB 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로, WB, IHC, Flow, IP 등 다양한 응용에 적합. 고순도 친화 크로마토그래피 정제, 안정적인 액상 형태. 인간 시료 반응성, 연구용으로만 사용.
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Thermo Fisher Scientific CRYAB Monoclonal Antibody (OTI3C2), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Flow Cytometry (Flow) | 1:100 |
| Immunoprecipitation (IP) | 2 µg/500 µL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3C2 |
| Immunogen | Full length human recombinant protein of human CRYAB produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found in vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index. The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma.
Alpha-crystallin is composed of two primary gene products, alpha-A and alpha-B, and comprises 40% of total lens protein composition. It functions as a molecular chaperone preventing aggregate formation that may lead to cataract development. Phosphorylation of alpha-crystallin occurs in response to cellular stress and may play a role in protein maintenance.
Alpha-B crystallin has been linked to Alexander’s disease, where it accumulates in brain cells of affected individuals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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