Thermo Fisher Scientific EYA2 Monoclonal Antibody (2F8)
EYA2 단백질을 표적으로 하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 2F8). Western blot, ICC/IF, ELISA에 사용 가능. 인간 반응성, 액상 형태, PBS 버퍼에 보존제 없음. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2F8 |
| Immunogen | EYA2 (NP_742108, 164 a.a. approximately 271 a.a) partial recombinant protein with GST tag. MW of GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
PASSICPSPL STSTYVLQEA SHNVPNQSSE SLAGEYNTHN GPSTPAKEGD TDRPHRASDG KLRGRSKRSS DPSPAGDNEI ERVFVWDLDE TIIIFHSLLT GTFASRYG
Target Information
Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4, and SIX5.
Tyrosine phosphatase that dephosphorylates Tyr-142 of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1.
Tyr-142 phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark distinguishing between apoptotic and repair responses to genotoxic stress.
Its function as histone phosphatase may contribute to transcription regulation during organogenesis.
Plays an important role in hypaxial muscle development together with SIX1 and DACH2; functionally redundant with EYA1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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