Thermo Fisher Scientific EYA2 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): 1–5 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MVELVISPSL TVNSDCLDKL KFNRADAAVW TLSDRQGITK SAPLRVSQLF SRSCPRVLPR QPSTAMAAYG QTQYSAGIQQ ATPYTAYPPP AQAYGIPSYS IKTEDSLNHS PGQSGFLSYG SSFSTSPTGQ SPYTYQMHGT TGFYQGGNGL GNAAGFGSVH QDYPSYPGFP QSQYPQYYGS SYNPPYVPAS SICPSPLSTS TYVLQEASHN VPNQSSESLA GEYNTHNGPS TPAKEGDTDR PHRASDGKLR GRSKRSSDPS PAGDNEIERV FVWDLDETII IFHSLLTGTF ASRYGKDTTT SVRIGLMMEE MIFNLADTHL FFNDLEDCDQ IHVDDVSSDD NGQDLSTYNF SADGFHSSAP GANLCLGSGV HGGVDWMRKL AFRYRRVKEM YNTYKNNVGG LIGTPKRETW LQLRAELEAL TDLWLTHSLK ALNLINSRPN CVNVLVTTTQ LIPALAKVLL YGLGSVFPIE NIYSATKTGK ESCFERIMQR FGRKAVYVVI GDGVEEEQGA KKHNMPFWRI SCHADLEALR HALELEYL

Target Information

Functions both as a protein phosphatase and as a transcriptional coactivator for SIX1, and likely also for SIX2, SIX4, and SIX5.

• Dephosphorylates Tyr-142 of histone H2AX (H2AXY142ph) to promote DNA repair through recruitment of MDC1-containing complexes.
• Plays a key role in distinguishing apoptotic versus repair responses to genotoxic stress.
• Contributes to transcription regulation during organogenesis.
• Important for hypaxial muscle development together with SIX1 and DACH2; functionally redundant with EYA1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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