Thermo Fisher Scientific Orosomucoid 2 Polyclonal Antibody

Thermo Fisher Scientific Orosomucoid 2 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:1,000
• Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent

Product Specifications

Target Information

AGP (α1-acid Glycoprotein) is an acute-phase plasma protein synthesized by the liver. It regulates interactions between blood cells and endothelial cells, and, together with haptoglobin and C-reactive protein, mediates cell extravasation during infection and inflammation. Expression of AGP is induced by acute-phase stimulatory agents such as bacterial lipopolysaccharides.
AGP exhibits high affinity, low capacity binding for basic drugs at physiological pH. In human plasma, AGP is typically found at levels of 0.5–1.4 mg/mL, which increase during acute inflammation; thus, AGP levels can serve as a diagnostic marker for inflammatory conditions.
Multiple AGP genes exist, including AGP-1, AGP-2, AGP-3, and AGP-8. AGP-1 and AGP-2 contain five and six potential N-glycosylation sites, respectively. Abnormal expression of the AGP-1 gene is linked to sarcoidosis and other immunogenetic diseases, while mutations in the AGP-2 gene are associated with various carcinomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.