Thermo Fisher Scientific CRHBP Polyclonal Antibody
CRHBP 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot과 IHC(Paraffin)에 최적화된 제품으로 인간, 마우스, 랫트 반응성. Protein A 정제, 고농도(1 mg/mL) 액상 형태로 안정적인 신뢰성 제공.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- Publications: [References]
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
- Publications: [References]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human CRHBP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Response to stress in mammals requires an intact hypothalamic-pituitary-adrenal axis. The proximal part of the response is mediated by secretion of corticotropin-releasing hormone (CRH) by the paraventricular nucleus of the hypothalamus.
CRH is a 41 amino acid peptide derived by enzymatic cleavage from a 191 amino acid preprohormone.
CRH is produced not only in the hypothalamus but also in peripheral tissues, such as T lymphocytes, and is highly expressed in human placenta.
Glucocorticoids stimulate placental CRH synthesis and secretion in primary cultures of human placenta, contrasting with glucocorticoid suppression of CRH expression in the hypothalamus.
The gene encoding CRH maps to human chromosome 8q13.
Human plasma contains a CRH-binding protein, CRH-BP (also designated CRF-BP), which inactivates CRH and may prevent inappropriate pituitary-adrenal stimulation in pregnancy.
The gene encoding CRF-BP maps to human chromosome 5q11.2–q13.3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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