Thermo Fisher Scientific GNA11 Polyclonal Antibody
Rabbit polyclonal antibody targeting human GNA11 protein for WB, IHC, and ELISA applications. Reacts with human, mouse, and rat samples. Affinity purified, liquid form, stored at -20°C. Suitable for research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 250–350 of human GNA11 (NP_0020582) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.46 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855187 |
Product Specific Information
Immunogen sequence:
ESKALFRTII TYPWFQNSSV ILFLNKKDLL EDKILYSHLV DYFPEFDGPQ RDAQAAREFI LKMFVDLNPD SDKIIYSHFT CATDTENIRF VFAAVKDTIL Q
Target Information
Heterotrimeric guanine nucleotide-binding proteins (G proteins) consist of α, β, and γ subunits and mediate the effects of hormones, neurotransmitters, chemokines, and sensory stimuli. Over 20 known Gα subunits are classified into four families—Gα(s), Gα(i/o), Gα(q), and Gα(12)—based on structural and functional similarities.
Phosphorylation of Tyr356 of Gα(q)/Gα(11) is essential for activation of the G protein, since phenylalanine substitution for Tyr356 alters receptor interaction and abolishes ligand-induced IP3 formation.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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