Thermo Fisher Scientific GLDC Polyclonal Antibody
GLDC 단백질을 인식하는 Thermo Fisher Scientific의 토끼 다클론 항체입니다. Western blot과 IHC(P)에서 검증되었으며, 인간, 마우스, 랫트에 반응합니다. 항원 친화 크로마토그래피로 정제되었고, PBS/glycerol 완충액에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GLDC. Recombinant protein control fragment (Product # RP-101852) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2642028 |
Product Specific Information
Immunogen sequence:
ILNANYMAKR LETHYRILFR GARGYVGHEF ILDTRPFKKS ANIEAVDVAK RLQDYGFHAP TMSWPVAGTL MVEPTESEDK AELDRFCDAM ISIRQEIADI EEGRIDPRVN PLKMSPHSLT CVTSSHWDRP YSREVAAFPL PFVKPENK
Sequence identity:
Highest antigen sequence identity to the following orthologs:
- Mouse: 96%
- Rat: 96%
Target Information
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components:
- P protein (a pyridoxal phosphate-dependent glycine decarboxylase)
- H protein (a lipoic acid-containing protein)
- T protein (a tetrahydrofolate-requiring enzyme)
- L protein (a lipoamide dehydrogenase)
The P protein binds to glycine and enables the methylamine group from glycine to be transferred to the T protein.
Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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