Thermo Fisher Scientific NCF2 Polyclonal Antibody
Human NCF2 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western Blot 및 Immunohistochemistry에 적합. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 연구용으로 NADPH oxidase 관련 질환 연구에 활용 가능.
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Thermo Fisher Scientific NCF2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NCF2. Recombinant protein control fragment (Product #RP-95408). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644514 |
Product Specific Information
Immunogen sequence:
QEESSPQSDI PAPPSSKAPG RPQLSPGQKQ KEEPKEVKLS VPMPYTLKVH YKYTVVMKTQ PGLPYSQVRD MVSKKLELRL EHTKLSYRPR DSNELVPLSE DSMKDAWGQV KNYCLTLWCE NTVGDQGFPD EPKESEKADA NNQTTEPQ
Highest antigen sequence identity to orthologs:
- Mouse: 76%
- Rat: 24%
Target Information
NCF2, NCF1, and a membrane-bound cytochrome b558 are required for activation of the latent NADPH oxidase, necessary for superoxide production.
Defects in NCF2 cause chronic granulomatous disease autosomal recessive cytochrome-b-positive type 2 (CGD2).
Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill ingested microbes, leading to life-threatening bacterial and fungal infections.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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