Thermo Fisher Scientific NCF2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human NCF2. Recombinant protein control fragment (Product #RP-95408). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NCF2,uniProtId:P19878-1,ncbiNodeId:9606,antigenRange:308-455,antigenLength:526,antigenImageFileName:PA5-51702_NCF2_P19878-1_Rabbit.svg,antigenImageFileNamePDP:PA5-51702_NCF2_P19878-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2644514

Product Specific Information

Immunogen sequence: QEESSPQSDI PAPPSSKAPG RPQLSPGQKQ KEEPKEVKLS VPMPYTLKVH YKYTVVMKTQ PGLPYSQVRD MVSKKLELRL EHTKLSYRPR DSNELVPLSE DSMKDAWGQV KNYCLTLWCE NTVGDQGFPD EPKESEKADA NNQTTEPQ

Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 24%.

Target Information

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Defects in NCF2 are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 2 (CGD2). Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.