Thermo Fisher Scientific CDKN2A (p16INK4a) Monoclonal Antibody (OTI5H5), TrueMAB
CDKN2A (p16INK4a) 단백질을 인식하는 Mouse Monoclonal 항체로, Western Blot 및 IHC(Paraffin)에서 검증됨. 인간 시료 반응성, 비결합형 액상 형태, 고순도 친화 크로마토그래피 정제. 세포주기 조절 및 종양 억제 연구용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:200–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5H5 |
| Immunogen | Full length human recombinant protein of human CDKN2A produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene generates several transcript variants differing in their first exons. At least three alternatively spliced variants encode distinct proteins, two of which are CDK4 kinase inhibitors. Another transcript contains an alternate first exon located 20 Kb upstream, encoding an ARF protein that stabilizes p53 by interacting with MDM2, preventing p53 degradation. Despite structural and functional differences, all variants contribute to cell cycle G1 control through CDK4 and p53 regulation. CDKN2A is frequently mutated or deleted in various tumors and is recognized as a key tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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